Dr. Rita Levi-Montalcini, a Revolutionary in the Study of the Brain, Dies at 103

Fabio Campana/European Pressphoto Agency

Rita Levi-Montalcini, the Italian Nobel laureate, in 2007.

Dr. Rita Levi-Montalcini, a Nobel Prize-winning neurologist who discovered critical chemical tools that the body uses to direct cell growth and build nerve networks, opening the way for the study of how those processes can go wrong in diseases like dementia and cancer, died on Sunday at her home in Rome. She was 103.

Her death was announced by Mayor Gianni Alemanno of Rome.

“I don’t use these words easily, but her work revolutionized the study of neural development, from how we think about it to how we intervene,” said Dr. Gerald D. Fishbach, a neuroscientist and professor emeritus at Columbia.

Scientists had virtually no idea how embryo cells built a latticework of intricate connections to other cells when Dr. Levi-Montalcini began studying chicken embryos in the bedroom of her house in Turin, Italy, during World War II. After years of obsessive study, much of it at Washington University in St. Louis with Dr. Viktor Hamburger, she found a protein that, when released by cells, attracted nerve growth from nearby developing cells.

In the early 1950s, she and Dr. Stanley Cohen, a biochemist also at Washington University, isolated and described the chemical, known as nerve growth factor — and in the process altered the study of cell growth and development. Scientists soon realized that the protein gave them a new way to study and understand disorders of neural growth, like cancer, or of degeneration, like Alzheimer’s disease, and to potentially develop therapies.

In the years after the discovery, Dr. Levi-Montalcini, Dr. Cohen and others described a large family of such growth-promoting agents, each of which worked to regulate the growth of specific cells. One, called epidermal growth factor and discovered by Dr. Cohen, plays a central role in breast cancer; in part by studying its behavior, scientists developed drugs to combat the abnormal growth.

In 1986, Dr. Levi-Montalcini and Dr. Cohen shared the Nobel Prize in Physiology or Medicine for their work.

Dr. Cohen, now an emeritus professor at Vanderbilt University, said Dr. Levi-Montalcini possessed a rare combination of intuition and passion, as well as biological knowledge. “She had this feeling for what was happening biologically,” he said. “She was an intuitive observer, and she saw that something was making these nerve connections grow and was determined to find out what it was.”

One of four children, Rita Levi-Montalcini was born in Turin on April 22, 1909, to Adamo Levi, an engineer, and Adele Montalcini, a painter, both Italian Jews who traced their roots to the Roman Empire. In keeping with the Victorian customs of the time, Mr. Levi discouraged his three daughters from entering college, fearing that it would interfere with their lives as wives and mothers.

It was not a future that Rita wanted. She had decided to become a doctor and told her father so. “He listened, looking at me with that serious and penetrating gaze of his that caused me such trepidation,” she wrote in her autobiography, “In Praise of Imperfection” (1988). He also agreed to support her.

She graduated summa cum laude from the University of Turin medical school in 1936. Two years later, Mussolini issued a manifesto barring non-Aryan Italians from having professional careers. She began her research anyway, setting up a small laboratory in her home to study chick embryos, inspired by the work of Dr. Hamburger, a prominent researcher in St. Louis who also worked with the embryos.

During World War II, the family fled Turin for the countryside, and in 1943 the invasion by Germany forced them to Florence. The family returned at the close of the war, in 1945, and Dr. Hamburger soon invited Dr. Levi-Montalcini to work for a year in his lab at Washington University.

She stayed on, becoming an associate professor in 1956 and a full professor in 1958. In 1962, she helped establish the Institute of Cell Biology in Rome and became its first director. She retired from Washington University in 1977, becoming a guest professor and splitting her time between Rome and St. Louis.

Italy honored her in 2001 by making her a senator for life.

An elegant presence, confident and passionate, she was a sought-after speaker until late in life. “At 100, I have a mind that is superior — thanks to experience — than when I was 20,” she said in 2009.

She never married and had no children. In addition to her autobiography, she was the author or co-author of dozens of research studies and received numerous professional awards, including the National Medal of Science.

“It is imperfection — not perfection — that is the end result of the program written into that formidably complex engine that is the human brain,” Dr. Levi-Montalcini wrote in her autobiography, “and of the influences exerted upon us by the environment and whoever takes care of us during the long years of our physical, psychological and intellectual development.”

This article has been revised to reflect the following correction:

Correction: December 30, 2012

An earlier version of this obituary misstated the year Mussolini issued a manifesto barring non-Aryan Italians from having professional careers. It was 1938, not 1936.

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Day Laborers at Premium on Storm-Wrecked Coast

Ozier Muhammad/The New York Times

Reina Vega and Victoriano de la Cruz worked in the cellar of a home in Bay Ridge, Brooklyn.

The day after the storm, Manuel Sinchi, like some other New Yorkers, gathered a few friends, hopped on his bicycle and headed down to badly stricken Coney Island to volunteer his services.

The next day, however, he started offering his services at his usual rate of $15 an hour.

A day laborer for whom making a living in recent years has meant often pointless idling on street corners for increasingly hard-to-get construction work, Mr. Sinchi said that owners of houses ravaged by Hurricane Sandy were now searching him out seven days a week. In the first weeks after the storm, he performed work that required muscle and a strong back, hauling waterlogged sofas and broken refrigerators out of flooded basements, stripping mold-infested walls and sweeping away mounds of sand from front yards. But, as homeowners turned to rebuilding, he has performed more skilled jobs, installing new wallboard, wood floors and bathroom tiles.

There has been so much demand that he was able to buy his two sons in Ecuador a computer, bicycles and new shoes.

“While we have lots of sorrow for those who lost everything, at the same time Sandy has done us a favor by creating jobs that were not there,” Mr. Sinchi said, speaking in Spanish.

His tale of finding fortune along the streets of ruined homes and upended lives is similar to those of hundreds of day laborers in New York City and its coastal suburbs. For a population accustomed to scraping by, Hurricane Sandy has been a boon, conjuring up demolition and construction work that has been mostly absent since the housing market’s collapse and providing a spike in remittances to families in Mexico, Central America and South America.

These mostly Hispanic workers, some of whom are in the country illegally, have suddenly become a ubiquitous and indispensable presence in seaside communities in New York and New Jersey, where residents who might once have spurned hiring them are racing to make their homes livable again as soon as possible. Despite the influx of volunteers — sometimes regarded as competitors by the day laborers — there is so much demand for their services that even women who have typically made a living as domestics are gathering on street corners and in front of hardware stores to help with the grueling work.

“Day laborers are like first responders to this crisis,” said Ligia M. Guallpa, director of the Workers Justice Project, which operates a shack alongside a shopping plaza in Bensonhurst, Brooklyn, where day laborers gather and contractors and homeowners come to hire them. Before the storm, fewer than 15 workers a week were sent out on jobs. Now that number has grown to 45.

In the first week after the storm hit, homeowners were desperate for help getting their lives back to something approaching normal. Some day laborers like Carmelo Hernandez, 46, a Mexican immigrant and tile installer, even bought headlamps so they could work at night, so great was the demand.

More recently, some workers said that jobs had slowed as cleaning up shifted to rebuilding, which had prompted homeowners to turn to licensed professionals for skilled tasks like plumbing, carpentry and electrical work. But other laborers said they expected the volume of work to pick up when homeowners received money from their insurance companies or from the Federal Emergency Management Agency.

Standing on a corner of 69th Street in Woodside, Queens, dozens of men waited in the early morning cold for contractors’ trucks to pass by. Each time a car stopped, the men would sprint to the window. After a brief negotiation — $15 an hour was the going rate, though some agreed to work for less — a few would climb inside and speed off.

One of them, Pedro Cabrera, 28, who is from Mexico, had worked 10 straight days in the Rockaways. Even though one homeowner vanished without paying him, he had made enough to buy new gloves to work in the wet and freezing buildings. Some owners told him to take anything he found, since it was all headed for the trash anyway — even a ring that he was able to pawn for $200 at a jewelry store. Still, it was painful, he said, being watched by a family whose hard-earned belongings he was throwing into the garbage.

Sarah Maslin Nir and Jessica Weisberg contributed reporting.

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India Ink: Delhi Rape Victim's Trauma 'Too Severe to Overcome'

A 23-year-old woman, whose rape in Delhi on Dec. 16 galvanized thousands to protest for better treatment of women, died on Saturday morning. The full statement from Kelvin Loh, chief executive of Mount Elizabeth Hospital, where she was being treated, is below:

“We are very sad to report that the patient passed away peacefully at 4.45am on 29 Dec 2012 (Singapore time). Her family and officials from the High Commission of India were by her side. The Mount Elizabeth Hospital team of doctors, nurses and staff join her family in mourning her loss.”

“The patient had remained in an extremely critical condition since admission to Mount Elizabeth Hospital in the morning of 27 Dec (Singapore time). Despite all efforts by a team of eight specialists in Mount Elizabeth Hospital to keep her stable, her condition continued to deteriorate over these two days. She had suffered from severe organ failure following serious injuries to her body and brain. She was courageous in fighting for her life for so long against the odds but the trauma to her body was too severe for her to overcome.”

“We are humbled by the privilege of being tasked to care for her in her final struggle. We acknowledge the faith the Indian Government and the patient’s family have placed with us to ensure the best care possible was indeed provided to her at Mount Elizabeth Hospital. We share their huge sadness at her passing and will work with the High Commission of India to provide the family support in this time of grief.”

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NHL makes new offer; lockout enters critical stage

NEW YORK (AP) — The NHL made a new offer to the players' association, hoping to spark talks toward ending the long lockout and saving the hockey season.

Deputy commissioner Bill Daly said Friday the league presented its proposal Thursday and was waiting for a response. The sides haven't met in person since a second round of talks with a federal mediator broke down Dec. 13.

The lockout has reached its 104th day, and the NHL said it doesn't want a season of less than 48 games. That means a deal would need to be reached mid-January.

"We delivered to the union a new, comprehensive proposal for a successor CBA," Daly said in a statement Friday. "We are not prepared to discuss the details of our proposal at this time. We are hopeful that once the union's staff and negotiating committee have had an opportunity to thoroughly review and consider our new proposal, they will share it with the players. We want to be back on the ice as soon as possible."

A person familiar with key points of the offer told The Associated Press that the league proposed raising the limit of individual free-agent contracts to six years from five — seven years if a team re-signs its own player; raising the salary variance from one year to another to 10 percent, up from 5 percent; and one compliance buyout for the 2013-14 season that wouldn't count toward a team's salary cap but would be included in the overall players' share of income.

The person spoke on condition of anonymity because details of the new offer were not being discussed publicly.

The NHL maintained the deferred payment amount of $300 million it offered in its previous proposal, an increase from an earlier offer of $211 million. The initial $300 million offer was pulled off the table after negotiations broke off earlier this month.

The latest proposal is for 10 years, running through the 2021-22 season, with both sides having the right to opt out after eight years.

A conference call with the players' association's negotiating committee and its executive board was scheduled for Friday afternoon and was expected to last several hours.

The lockout has reached a critical stage, threatening to shut down a season for the second time in eight years. All games through Jan. 14, plus the Winter Classic and the All-Star game already have been called off. The next round of cuts could claim the entire schedule.

The NHL is the only North American professional sports league to cancel a season because of a labor dispute, losing the 2004-05 campaign to a lockout. A 48-game season was played in 1995 after a lockout stretched into January.

It is still possible this dispute could eventually be settled in the courts if the sides can't reach a deal on their own.

The NHL filed a class-action suit this month in U.S. District Court in New York in an effort to show its lockout is legal. In a separate move, the league filed an unfair labor practice charge with the National Labor Relations Board, contending bad-faith bargaining by the union.

Those moves were made because the players' association took steps toward potentially filing a "disclaimer of interest," which would dissolve the union and make it a trade association. That would allow players to file antitrust lawsuits against the NHL.

Union members voted overwhelmingly to give their board the power to file the disclaimer by Jan. 2. If that deadline passes, another authorization vote could be held to approve a later filing.

Negotiations between the NHL and the union have been at a standstill since talks ended Dec. 6. One week later, the sides convened again with federal mediators in New Jersey, but still couldn't make progress.

The sides have been unable to reach agreement on the length of the new deal, the length of individual player contracts, and the variance in salary from year to year. The NHL is looking for an even split of revenues with players.

The NHL pulled all previous offers off the table after the union didn't agree to terms on its last proposal without negotiation.

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Surgery Returns to NYU Langone Medical Center

Chang W. Lee/The New York Times

Senator Charles E. Schumer spoke at a news conference Thursday about the reopening of NYU Langone Medical Center.

NYU Langone Medical Center opened its doors to surgical patients on Thursday, almost two months after Hurricane Sandy overflowed the banks of the East River and forced the evacuation of hundreds of patients.

While the medical center had been treating many outpatients, it had farmed out surgery to other hospitals, which created scheduling problems that forced many patients to have their operations on nights and weekends, when staffing is traditionally low. Some patients and doctors had to postpone not just elective but also necessary operations for lack of space at other hospitals.

The medical center’s Tisch Hospital, its major hospital for inpatient services, between 30th and 34th Streets on First Avenue, had been closed since the hurricane knocked out power and forced the evacuation of more than 300 patients, some on sleds brought down darkened flights of stairs.

“I think it’s a little bit of a miracle on 34th Street that this happened so quickly,” Senator Charles E. Schumer of New York said Thursday.

Mr. Schumer credited the medical center’s leadership and esprit de corps, and also a tour of the damaged hospital on Nov. 9 by the administrator of the Federal Emergency Management Agency, W. Craig Fugate, whom he and others escorted through watery basement hallways.

“Every time I talk to Fugate there are a lot of questions, but one is, ‘How are you doing at NYU?’ ” the senator said.

The reopening of Tisch to surgery patients and associated services, like intensive care, some types of radiology and recovery room anesthesia, was part of a phased restoration that will continue. Besides providing an essential service, surgery is among the more lucrative of hospital services.

The hospital’s emergency department is expected to delay its reopening for about 11 months, in part to accommodate an expansion in capacity to 65,000 patient visits a year, from 43,000, said Dr. Andrew W. Brotman, its senior vice president and vice dean for clinical affairs and strategy.

In the meantime, NYU Langone is setting up an urgent care center with 31 bays and an observation unit, which will be able to treat some emergency patients. It will initially not accept ambulances, but might be able to later, Dr. Brotman said. Nearby Bellevue Hospital Center, which was also evacuated, opened its emergency department to noncritical injuries on Monday.

Labor and delivery, the cancer floor, epilepsy treatment and pediatrics and neurology beyond surgery are expected to open in mid-January, Langone officials said. While some radiology equipment, which was in the basement, has been restored, other equipment — including a Gamma Knife, a device using radiation to treat brain tumors — is not back.

The flooded basement is still being worked on, and electrical gear has temporarily been moved upstairs. Mr. Schumer, a Democrat, said that a $60 billion bill to pay for hurricane losses and recovery in New York and New Jersey was nearing a vote, and that he was optimistic it would pass in the Senate with bipartisan support. But the measure’s fate in the Republican-controlled House is far less certain.

The bill includes $1.2 billion for damage and lost revenue at NYU Langone, including some money from the National Institutes of Health to restore research projects. It would also cover Long Beach Medical Center in Nassau County, Bellevue, Coney Island Hospital and the Veterans Affairs hospital in Manhattan.

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Obama to Urge Vote in Senate if Parties Fail in Fiscal Talks

Luke Sharrett for The New York Times

In a televised statement at the White House after meeting with Congressional leaders on Friday, President Obama said he was “modestly optimistic” that an agreement could be reached.

WASHINGTON — President Obama said Friday evening that progress had been made in make-or-break talks on the fiscal crisis and pronounced himself cautiously “optimistic,” as Senate leaders worked furiously toward an agreement to avert the worst of the economic punch from landing Jan. 1.

But after a one-hour meeting with Congressional leaders at the White House, Mr. Obama warned that if the two sides did not agree on a bill, he would urge the Democratic-controlled Senate to put forward a measure anyway, in essence daring Republicans in the House and Senate to block a floor vote on tax cuts.

“I believe such proposals could pass both houses with a bipartisan majority as long as both leaders will allow it to come to a vote,” Mr. Obama said. “If members want to vote no, they can.”

Senators broke from a long huddle on the Senate floor with Senator Mitch McConnell of Kentucky, the Republican leader, to say progress had been made. Mr. McConnell, White House aides, and Senator Harry Reid of Nevada, the majority leader, were set to continue talks on Saturday aiming for a breakthrough as soon as Sunday.

“We’re working with the White House, and hopefully we’ll come up with something we can recommend to our respective caucuses,” Mr. McConnell told reporters.

Mr. Reid also said that there had been some progress but he warned that in assembling a measure that can win support from both parties, “what we come up with is going to be imperfect.”

For all the cautious optimism, the president also expressed exasperation that four days before a looming deadline, which lawmakers have known about for a year and a half, the two sides are still far apart.

“This is déjà vu all over again,” he said. “America wonders why it is that in this time, you can’t get stuff done in an organized timetable. The American people are not going to have any patience for a politically self-inflicted wound to our economy.”

Mr. Obama took steps to keep the pressure on throughout the weekend, scheduling an appearance on Sunday’s “Meet the Press” on NBC.

The emerging path to a possible resolution, at least Friday, appeared to mirror the protracted stalemate over the payroll tax cut last year. In that conflict, House Republicans refused to go along with a short-term extension of the cut, but Mr. McConnell struck a deal that permitted such a measure to get through the Senate, and Speaker John A. Boehner essentially forced members of the House to accept it from afar, after members had left for Christmas recess.

This time, the consequences are even more significant, with more than a half-trillion dollars of tax increases and across-the-board spending cuts just days from going into force, an event most economists warn would send the economy back into recession if not quickly reversed. With the House set to return to the Capitol on Sunday, Mr. Boehner has said he would place any Senate-passed bill before his chamber — perhaps amended — and let the chips fall, with or without Republicans on board.

“I’ve got a positive feeling now,” said Senator Kay Bailey Hutchison, Republican of Texas, who said a burst of deal-making talk broke out as soon as the leaders returned to the Capitol.

This was the first time in weeks that Mr. Obama met with the four Congressional leaders — Mr. Reid, Mr. McConnell, Mr. Boehner and Representative Nancy Pelosi, the Democratic leader.

The meeting started with the president reiterating his demand for an extension of tax cuts on incomes below $250,000.

That opening offer lowered expectations on Capitol Hill that a breakthrough could be pending, but behind the scenes, talks continued, focusing on a possibly higher threshold of $400,000. Senator Max Baucus of Montana, chairman of the Senate Finance Committee, said sentiment is “jelling” around a new offer, and a source familiar with the negotiations said the president would ask Republican and Democratic leaders what proposal could win majority support in the House and Senate.

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Iran’s Slowing of Enrichment Efforts May Show It Wants Deal

WASHINGTON — By subtly putting its hands on the brakes of its uranium enrichment efforts, Iran may be signaling that it wants to avoid a direct confrontation over its nuclear program, at least in the near term, according to United States and other Western officials.  The action has also led some analysts to conclude that Iran’s leaders are showing signs that they may be more interested in a deal to end the nuclear standoff with the West.  

Evidence began emerging last summer that the Iranians were diverting a significant portion of their medium-enriched uranium for use in a small research reactor, converting it into a form that cannot easily be used in a weapon.

One American official said the move amounted to trying to “put more time on the clock to solve this,” characterizing it as a step “you have to assume was highly calculated, because everything the Iranians do in a negotiation is highly calculated.” Israel’s departing defense minister, Ehud Barak, came to a similar conclusion when he said in October that his country could safely back away from threats of military action against Iran, at least until the late spring or summer of 2013.

But White House, State Department and Pentagon officials all cautioned against drawing firm conclusions about Iran’s ultimate intentions.

A new session of talks involving Iran and six major powers, including the United States, is expected next year, and American officials say they still cannot determine whether Iran’s supreme leader, Ayatollah Ali Khamenei, is ready to strike a deal.

A quiet feeler seeking direct talks with Iran that the administration put out after President Obama’s re-election last month resulted in “no real response,” another senior official said, adding: “It wasn’t that they said yes or no. They said nothing.”

These uncertainties underlie the hunger in Western countries to understand why Iran appears to be keeping its stockpile of medium-enriched uranium — which could be converted to bomb fuel in weeks or months — to a level below the amount necessary to build a single weapon.

Evidence from a variety of sources, including the International Atomic Energy Agency, suggests that as Iran produced more uranium enriched to near 20 percent purity, a process that takes it most of the way to bomb-grade fuel, it began diverting some into an oxide powder that could be used in a small research reactor in Tehran. That diversion is believed to have begun in August.

Iran had been complaining for years that the research reactor, which was supplied by the United States during the rule of Shah Mohammed Reza Pahlavi to produce isotopes for medical purposes, was running out of fuel, and that the West refused to sell it more. So it decided to make the fuel itself. Now, even though it has enough fuel to keep the reactor running for at least a decade, it may be making more, several sources indicate.

The statistics released in quarterly reports by the atomic energy agency show that if Iran had not diverted fuel to that project, it would have enough medium-enriched fuel for one bomb and would be on its way to enough for a second. Instead, as of the agency’s last report, in November, Iran had enriched 232 kilograms (about 511 pounds) of the fuel, nearly enough to produce a weapon. But more than 96 kilograms (almost 212 pounds) had been sent off for fabrication into fuel plates for the reactor. Once turned to that purpose, the fuel is very difficult to use in a bomb.

The diversion “was a move to take heat away so that things didn’t go over the tipping point,” said Olli Heinonen, the former head of inspections for the atomic energy agency, who dealt with Iran extensively. Mr. Heinonen, now a senior fellow at the Kennedy School of Government at Harvard, said that since the diversion, the Iranians had continued to produce about 15 kilograms (about 33 pounds) a month of medium-enriched fuel. So unless they slow that pace, or divert more fuel to the reactor program, “they are going back up to the tipping point,” he said.

Iran could use that to its advantage in negotiations. “I think it is hard to understand what Iran was doing if not sending a deliberate signal, signaling some cautiousness,” said Greg Thielmann, a former State Department intelligence analyst who is now at the Arms Control Association. “I think it is reasonable to see the diversion as a negotiating signal, and a note of moderation.”

Ray Takeyh, an Iran specialist at the Council on Foreign Relations, said that “the sanctions policy that the United States has pursued over the past decade is beginning to bear fruit.” He said that the steps, which have led to a huge devaluation of the Iranian currency and a sharp decline in Iranian oil exports, “have seemingly succeeded in convincing influential sectors of the theocracy to reconsider their options.”

Some Arab officials agree, though they warn that it could be three years before the sanctions hurt Iran enough to bring about a change of position. “The problem is we don’t have three years,” a senior Arab diplomat said recently.

The big question is whether any of this is more than tactical positioning. “Tehran almost certainly hopes the diversion will be read in Western capitals as a sign of its willingness to reach a deal,” said Paul R. Pillar, a former C.I.A. analyst who is now at Georgetown University.

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Net loss: Brooklyn fires coach Avery Johnson

NEW YORK (AP) — Coach of the month in November, out of a job by New Year's.

The Brooklyn Nets have elevated expectations this season, and a .500 record wasn't good enough. Coach Avery Johnson was fired Thursday, his team having lost 10 of 13 games after a strong start to its first season in Brooklyn.

"We don't have the same fire now than we did when we were 11-4," general manager Billy King said at a news conference in East Rutherford, N.J. "I tried to talk to Avery about it and we just can't figure it out. The same pattern kept on happening."

Assistant P.J. Carlesimo will coach the Nets on an interim basis, starting Friday night with a home game against Charlotte. King said the Nets might reach out to other candidates, but for now the job was Carlesimo's. The GM wouldn't comment on a report that the team planned to get in touch with former Lakers coach Phil Jackson.

King said the decision to dismiss Johnson was made by ownership after a phone discussion Thursday morning. Owner Mikhail Prokhorov had expressed faith in Johnson before the season.

"With the direction we were going we felt we had to make a change," King said.

Johnson was in the final year of a three-year, $12 million contract.

"It's a really disappointing day for me and my family. It's my wife's birthday. It's not a great birthday gift," Johnson said. "I didn't see this coming. But this is ownership's decision. It's part of the business. Fair or unfair, it's time for a new voice and hopefully they'll get back on track."

The Nets have fallen well behind the first-place New York Knicks, the team they so badly want to compete with in their new home. But after beating the Knicks in their first meeting Nov. 26, probably the high point of Johnson's tenure, the Nets went 5-10 and frustrations have been mounting.

"Our goal is to get to the conference finals," King said. "We started out good and then we stumbled. We have to get back to playing winning basketball. It's the entire team. It's not like golf, where Tiger Woods can blame the caddie. It takes five guys on the court and they're all struggling. We have to figure out the ways to get back to winning. I don't know what happened. I'm not sure. But unfortunately, it did happen."

The Nets were embarrassed by Boston on national TV on Christmas, then were routed by Milwaukee 108-93 on Wednesday night for their fifth loss in six games.

Star guard Deron Williams recently complained about Johnson's offense, and Nets CEO Brett Yormark took to Twitter after the loss to Celtics to voice his displeasure with the performance.

King said the change was not made because Williams was unhappy, and he added the point guard himself has to play better.

Johnson also stood by Williams.

"From Day One, I always had a really good relationship with him. I don't think it's fair for anyone to hang this on Deron," Johnson said. "We were just going through a bad streak, a bad spell. It's not time for me to be down on one player. That would be the easy way."

Brooklyn started the season 11-4, winning five in a row to end November, when Johnson was Eastern Conference coach of the month. But he couldn't do anything to stop this slump, one the Nets never anticipated after a $350 million summer spending spree they believed would take them toward the top of their conference.

Johnson has been the Nets' coach for a little more than two seasons. He went 60-116 with the Nets, who moved from New Jersey to Brooklyn to start the season. Johnson coached the Dallas Mavericks to a spot in the NBA Finals in 2006.

"You don't always get a fair shake as a coach," Johnson said. "I'm not the owner. If I were the owner, I wouldn't have fired myself today. But life is not always necessary fair. It's a business and in this business, the coach always gets blamed."

This is the NBA's second coaching change this season following the dismissal of Mike Brown by the Los Angeles Lakers.

Johnson arrived in New Jersey with a 194-70 record, a .735 winning percentage that was the highest in NBA history, but had little chance of success in his first two seasons while the Nets focused all their planning on the move to Brooklyn.

They looked to make a splash this summer when they re-signed Williams and fellow starters Gerald Wallace, Brook Lopez and Kris Humphries, traded for Atlanta All-Star Joe Johnson, and added veteran depth with players such as Reggie Evans, C.J. Watson and Andray Blatche.

Johnson didn't have a contract beyond this season but seemed to have the confidence of Prokhorov, the Russian billionaire who before the season said he had faith in "the Avery defense system."

Some thought the Nets would finish as high as second in the East behind defending champion Miami, and the predictions seemed warranted when the Nets started quickly amid much fanfare. But all the good publicity faded in recent weeks once the losing started.

Williams, who has struggled this season, stirred the waters when he expressed his preference for the offense he ran under Jerry Sloan in Utah before a loss to the Jazz. Williams and Johnson, nicknamed "Brooklyn's Backcourt" and expected to be one of the best in the NBA, have shot poorly and rarely meshed.

The Nets were embarrassed near the end of their 93-76 loss to Boston, when fans exited early amid a chant of "Let's go Celtics!"

"Nets fans deserved better," Yormark tweeted after the game. "The entire organization needs to work harder to find a solution. We will get there."

Not under Johnson, though.

The Nets should be able to entice a big-name coach with Prokhorov's billions and the chance to play in a major market at Barclays Center, the $1 billion arena that has drawn praise in the city and from visiting teams.

Carlesimo has previous NBA head coaching experience in Portland, Golden State and Seattle/Oklahoma City. He has a career coaching record of 204-296 in the regular season and 3-9 in the playoffs.

"Right now, P.J. is our coach and I told him to coach the team like he'll be here for the next 10 years," King said.

___

AP Sports Writer Tom Canavan in East Rutherford and AP freelancer Jim Hague contributed to this report.

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Syrian General in Charge of Stopping Defections Becomes a Defector

Aref Heretani/Reuters.

Mannequins were set up to confuse snipers loyal to President Bashar al-Assad in the old city of Aleppo on Sunday.

BEIRUT, Lebanon — Syria’s government suffered an embarrassing new setback as the top general responsible for preventing defections within the military became a defector himself, making what insurgents described on Wednesday as a daring back-roads escape by motorcycle across the border into Turkey.

The defector, Maj. Gen. Abdul Aziz Jassem al-Shallal, the chief of the military police, was one of the highest-ranking military officers to abandon President Bashar al-Assad in the nearly two-year-old uprising against him.

His departure, first reported by Al Arabiya late on Tuesday evening and confirmed by opposition figures on Wednesday, came as a flurry of diplomatic activity suggested the possibility of movement toward a political solution to the Syrian crisis. A deputy Syrian foreign minister flew to Moscow for meetings with Kremlin officials, and the international envoy who met with Mr. Assad in Damascus earlier this week was planning to visit Moscow this weekend. Russia, one of Mr. Assad’s most ardent foreign defenders, has in recent weeks suggested it was open to a negotiated transition that would ease him out of power.

Opposition figures said General Shallal’s defection had taken weeks to prepare and ended with a four-hour sprint by motorcycle to the Turkish border, driving through woods and on muddy roads. In a video broadcast by Al Arabiya, the general said that he had taken the step because the Syrian military had deviated from its mission to protect the country, and had transformed into “a gang for killing and destruction.”

“The regime army has lost control over most of the country,” the general said in an interview on the Saudi-owned channel, which has heavily criticized the Syrian government.

Opposition fighters embraced the defection as more than a symbolic blow to the government because of the general’s primary responsibility as an enforcer of Mr. Assad’s repression of dissent and guarantor of loyalty by the armed forces. As head of the military police, General Shallal was responsible for the department that was supposed to stop defections. He also presided over a force that guarded prisons where civilian dissidents were held.

Maj. Ibrahim Moutawe, who defected from the Syrian Army a year ago, said defection was a “last resort” for high-ranking officials like General Shallal. “They only consider it when fear and danger begin to threaten them directly, and when the regime can no longer protect them,” he said.

General Shallal was not a member of Mr. Assad’s inner circle, and analysts said that the defections of other officials with impressive titles — including the prime minister, a brigadier general and a well-known government spokesman — had done little to shake Mr. Assad’s basic hold on power.

More critically, the opposition has failed to attract either officers or rank-and-file soldiers belonging to Syria’s Alawite minority, the sect that Mr. Assad belongs to, doing little to assuage fears among Alawites that the Sunni-led insurgency threatens their existence, analysts said.

But the departure of a major general who publicly condemned the armed forces seemed likely to undercut Mr. Assad’s attempts to maintain morale.

The negotiations for the general’s defection began weeks ago, after members of his tribe reached out to opposition commanders, according to Louay Mekdad, the political and media coordinator for the Free Syrian Army, an umbrella organization for rebel fighting groups. Mr. Mekdad said that the general had tried to defect several times before, but had been prevented for what he called “technical reasons,” without giving any more detail.

Rebel commanders gave differing accounts of how much power the general had held in Syria. One commander said he had been a member of Mr. Assad’s “crisis team” of top military, security and intelligence officials coordinating the government’s response to the war. Capt. Adnan Dayoub, a rebel commander in Hama, said that General Shallal had been responsible for prisons — “God knows how many,” he said — and was almost certainly guilty of crimes.

“He’s contaminated from top to bottom,” the captain said. “Tomorrow he will be a hero.”

Kareem Fahim reported from Beirut, and Rick Gladstone from New York. Reporting was contributed by Hwaida Saad from Beirut, Ellen Barry from Moscow, Hala Droubi from Dubai, United Arab Emirates, and Eric Schmitt from Washington.

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Peyton Manning, Peterson make Pro Bowl

NEW YORK (AP) — Peyton Manning and Adrian Peterson want to cap their sensational comebacks with Super Bowl appearances. For now, they can be proud of Pro Bowl spots.

So can Redskins quarterback Robert Griffin III, one of two rookies chosen Wednesday for the Jan. 27 NFL all-star game.

Manning missed all of the 2011 season with neck and back problems that required several operations. He then signed with Denver as a free agent and has led the Broncos on a 10-game winning streak to take the AFC West.

"I know there's great players out there in the NFL, but there's some great players on this team this year that deserve to go," said Manning, whose 12th Pro Bowl is a record for quarterbacks. He ranks fourth in league passing this year, has thrown 34 touchdowns and 11 interceptions.

Four other Broncos made the AFC roster: DE Elvis Dumervil, linebacker Von Miller, CB Champ Bailey and tackle Ryan Clady. Bailey's 12th appearance is a record for defensive backs.

"My goal has always been to go out and help the team win and play at a high level," Manning added. "Anything that comes along with that, like being honored as a Pro Bowl selection, is very humbling."

Minnesota's Peterson tore up his left knee on Christmas Eve last year, underwent major surgery, then was back for the season opener. He's gone from uncertain to unstoppable, running away with the rushing title with a career-high 1,898 yards and lifting the Vikings toward an NFC wild card.

"Coming into the season after going through the rehab process, I just told myself that I wanted to lead my team to a championship and make sure that I contribute and do my part," Peterson said. "I've been doing it."

Griffin is one of three rookie QBs who had superb debut seasons, along with Andrew Luck of Indianapolis and Russell Wilson of Seattle. Luck and Wilson weren't voted to the Pro Bowl by players, coaches and fans, although their teams are in the playoffs; Griffin can get to the postseason if Washington beats Dallas on Sunday.

"You can't play down those kind of things," Griffin said. "I've always said my whole football career that you don't play for awards. They just come. You don't say you're going to win the Heisman. You don't say you're going to win MVP. You go out and you prove it on the field, and if everyone feels that way then they'll give you that award."

San Francisco had the most players selected, nine, including six from its second-ranked defense. Houston was next with eight, six on offense.

Kansas City, despite its 2-13 record that is tied with Jacksonville for worst in the league, had five Pro Bowlers, including RB Jamaal Charles, who like Peterson is coming back from a torn ACL.

One other rookie, Minnesota kicker Blair Walsh, was chosen. Walsh has nine field goals of at least 50 yards, an NFL mark.

The AFC kicker is at the other end of the spectrum: Cleveland's Phil Dawson earned his first selection in his 14th NFL season.

Another record setter will be heading to Honolulu: Detroit WR Calvin Johnson.

Johnson broke Jerry Rice's single-season yards receiving record and has 1,892 yards with a game left.

Falcons tight end Tony Gonzalez set the record for Pro Bowls at his position by being chosen for the 13th time.

The league's top two sackmasters, DEs Aldon Smith of San Francisco and J.J. Watt of Houston, were first-time selections. Watt has 20 1-2 sacks, one ahead of Smith; the NFL record is 22 1-2.

Other newcomers, along with Griffin, Walsh and Dawson, were AFC players tackle Duane Brown and guard Wade Smith of Houston; safety LaRon Landry of the Jets; kick returner Jacoby Jones of Baltimore; and punter Dustin Colquitt of Kansas City.

For the NFC, first-timers were Giants WR Victor Cruz; Atlanta WR Julio Jones; Seattle tackle Russell Okung and center Max Unger; San Francisco guard Mike Iupati, linebacker NaVorro Bowman and safety Donte Whitner; Chicago cornerback Tim Jennings and defensive tackle Henry Melton; Washington tackle Trent Williams and special teamer Lorenzo Alexander; Minnesota fullback Jerome Felton; Tampa Bay DT Gerald McCoy; and New Orleans punter Thomas Morstead.

Eight teams had no Pro Bowl players: Carolina, Philadelphia and St. Louis in the NFC, Tennessee, Buffalo, Jacksonville, San Diego and Oakland in the AFC.

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Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

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