The Lede Blog: Live Updates on Armstrong's Oprah Interview

The Lede is rounding up online reaction to Lance Armstrong’s interview with Oprah Winfrey on Thursday night in real-time, with additional fact-checking and context provided by Juliet Macur and Sarah Lyall. The broadcast begins at 9 p.m. Eastern Time and will be streamed live on the Oprah Winfrey Network’s Web site.

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Video game puts players in shoes of Syrian rebels

BEIRUT (AP) — A new video game based on Syria‘s civil war challenges players to make the hard choices facing the country’s rebels. Is it better to negotiate peace with the regime of President Bashar Assad, for example, or dispatch jihadist fighters to kill pro-government thugs?

The British designer of “Endgame: Syria” says he hopes the game will inform people who might otherwise remain ignorant about the conflict.

Views differ, however, on the appropriateness of using a video game to discuss a complex crisis that has killed more than 60,000 people since March 2011. Computer giant Apple has refused to distribute the game and some consider the mere idea insulting. Others love it, and one fan from inside Syria has suggested changes to make the game better mirror the actual war.

The dispute comes amid wider arguments about violent video games since last month’s shooting in Newtown, Connecticut, that left 20 children and six adults dead. This week, the National Rifle Association revised the recommended age for a new shooting game after criticisms by liberal groups.

Tomas Rawlings, who designed the Syria game, said he got the idea while watching TV pundits debate the possible consequences of directly arming Syria’s rebels, which Western nations have declined to do. He said he thought a game could explore such questions by allowing players to make choices and see their consequences.

“For those who don’t want to read a newspaper but still care about the world, this is a way for them to find out about things,” said Rawlings, the design and production director of U.K.-based Auroch Digital.

In the simple game, which took about two weeks to build, the player assumes the role of the rebels seeking to topple Assad’s regime. The play alternates between political and military stages. In each stage, the player sees cards representing regime actions and must choose the rebel response.

The choices seek to mirror the real conflict. The regime may get declarations of support from Russia, China or Iran to boost its popularity while the rebels receive support from the United States, Turkey or Saudi Arabia – reflecting the foreign powers backing the two sides.

In battle, the regime may deploy conventional military forces like infantry, tanks and artillery as well as pro-government thugs known as shabiha. The rebels’ choices include sympathetic Palestinian or Kurdish militias, assassins or jihadist fighters known as muhajideen.

Some of the rebels’ strongest attacks also kill civilians, reducing rebel popularity and seeking to reflect the war’s complexity.

All along, the player is given basic information about the conflict, learning that Islamists once persecuted by the regime now consider the fight a holy war and that the shabiha are accused of massacring civilians.

The game ends when one side loses its support or the sides agree to a peace deal. The player is then told what follows. The longer the fighting lasts, the worse the aftermath, as chaos, sectarian conflict and Islamic militancy spread.

The lasting impression is that no matter which side wins, Syria loses.

Rawlings said that’s the game’s point.

“You can win the battle militarily but still lose the peace because the cost of winning militarily has fractured the country so much that the war keeps going,” he said. “You can also end the war so that there is less of that.”

The game was released on the company’s website and as a free download from Google for Android devices on December 12. Rawlings submitted the game to Apple to distribute via its App Store but the company rejected it.

Apple declined to comment, but Rawlings’s rejection referred to a company guideline for mobile apps: ” ‘Enemies’ within the context of a game cannot solely target a specific race, culture, a real government or corporation, or any other real entity.”

Rawlings is modifying the game, though he worries it will weaken it.

“It will still be the same overall experience, but it will reduce the value of the game to inform people,” he said.

News of the game was greeted with a mix of interest and outrage online. Some complained that players can’t take the regime side, while others found it wrong to make a game about a brutal war.

“Rawlings has mistakenly understood the Syrian war as a nonchalant ‘experience’ that people can play while waiting for the train to work,” said Samar Aburahma, a university student of Palestinian descent in San Francisco who refused to try the game. “It is beyond insulting to Syrians, especially given the fact that war is ongoing.”

Others find it a valuable, if limited, approach to the conflict.

Andrea Stanton, a religious studies professor at the University of Denver who studies Syria, said she responded emotionally to the game.

“It isn’t really a fun game to play,” she said, noting that she was angry when she lost and felt dread when the frequency of deadly regime airstrikes went up as the game progressed – as it has in the real conflict.

“This a very sobering game in that you sense how quickly the military stakes escalate and how little the political phase has to do with actual Syrians,” she said.

She is organizing a campus activity for students to play and discuss the game.

“I think it is very valuable for teaching and getting people to experience a sense of the limited options the rebels face,” she said.

It is unclear how many people have played the game. Google says it has been downloaded as many as 5,000 times from its site, and Rawlings says more have played online. He guesses more than 10,000 people have tried it.

Few in Syria are likely to have played it, since fighting has made the Internet and even electricity rare in some parts of the country.

One 18-year-old Syrian gamer liked the game so much, however, that he sent Rawlings a list of suggestions for improvement.

Reached via Skype, he said the jihadist fighters should be called Jabhat al-Nusra, after an extremist rebel group that the U.S. has designated as a terrorist organization.

He also pointed out that few rebel groups have tanks, as they do in the game, and suggested new rebel tactics.

“Car bombs are used lots in Syria, so that would make the game more realistic,” he said.

He said he hoped the game would help people understand the situation.

“I wish there were a 3D strategy game about Syria so you could feel the destruction on the ground,” he said.

The player, who spoke on condition of anonymity for fear of reprisals, said his feelings playing the game often mirror his feelings about the war. He wants peace but can’t imagine the rebels accepting a negotiated solution given how many people have died.

“Right this second, I want the war in Syria to stop, but when you see what is happening on the ground there is no way to make peace,” he said. “When I play the game like a rebel, I have to reject the peace.”

___

Associated Press writer Michael Liedtke contributed reporting.

Online: http://gamethenews.net/index.php/endgame-syria/

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Te'o mentioned 'girlfriend' twice recently

SOUTH BEND, Ind. (AP) — Not once but twice after he supposedly discovered his online girlfriend of three years never even existed, Notre Dame All-American linebacker Manti Te'o perpetuated the heartbreaking story about her death.

An Associated Press review of news coverage found that the Heisman Trophy runner-up talked about his doomed love in a Web interview on Dec. 8 and again in a newspaper interview published Dec. 10. He and the university said Wednesday that he learned on Dec. 6 that it was all a hoax, that not only wasn't she dead, she wasn't real.

On Thursday, a day after Te'o's inspiring, playing-through-heartache story was exposed as a bizarre lie, Te'o and Notre Dame faced questions from sports writers and fans about whether he really was duped, as he claimed, or whether he and the university were complicit in the hoax and misled the public, perhaps to improve his chances of winning the Heisman.

Yahoo sports columnist Dan Wetzel said the case has "left everyone wondering whether this was really the case of a naïve football player done wrong by friends or a fabrication that has yet to play to its conclusion."

Gregg Doyel, national columnist for CBSSports.com, was more direct.

"Nothing about this story has been comprehensible, or logical, and that extends to what happens next," he wrote. "I cannot comprehend Manti Te'o saying anything that could make me believe he was a victim."

On Wednesday, Te'o and Notre Dame athletic director Jack Swarbrick said the player was drawn into a virtual romance with a woman who used the phony name Lennay Kekua, and was fooled into believing she died of leukemia in September. They said his only contact with the woman was via the Internet and telephone.

Te'o also lost his grandmother — for real — the same day his girlfriend supposedly died, and his role in leading Notre Dame to its best season in decades endeared him to fans and put him at the center of college football's biggest feel-good story of the year.

Relying on information provided by Te'o's family members, the South Bend Tribune reported in October that Te'o and Kekua first met, in person, in 2009, and that the two had also gotten together in Hawaii, where Te'o grew up.

Sports Illustrated posted a previously unpublished transcript of a one-on-one interview with Te'o from Sept. 23. In it, he goes into great detail about his relationship with Kekua and her physical ailments. He also mentioned meeting her for the first time after a game in California.

"We met just, ummmm, just she knew my cousin. And kind of saw me there so. Just kind of regular," he told SI.

Among the outstanding questions Thursday: Why didn't Te'o ever clarify the nature of his relationship as the story took on a life of its own?

Te'o's agent, Tom Condon, said the athlete had no plans to make any public statements Thursday in Bradenton, Fla., where he has been training with other NFL hopefuls at the IMG Academy.

Notre Dame said Te'o found out that Kekua was not a real person through a phone call he received at an awards ceremony in Orlando, Fla., on Dec. 6. He told Notre Dame coaches about the situation on Dec. 26.

The AP's media review turned up two instances during that gap when the football star mentioned Kekua in public.

Te'o was in New York for the Heisman presentation on Dec. 8 and, during an interview before the ceremony that ran on the WSBT.com, the website for a South Bend TV station, Te'o said: "I mean, I don't like cancer at all. I lost both my grandparents and my girlfriend to cancer. So I've really tried to go to children's hospitals and see, you know, children."

In a column that first ran in The Los Angeles Times, on Dec. 10, Te'o recounted why he played a few days after he found out Kekua died in September, and the day she was supposedly buried.

"She made me promise, when it happened, that I would stay and play," he said on Dec. 9 while attending a ceremony in Newport Beach, Calif., for the Lott Impact Awards.

On Wednesday, when Deadspin.com broke the story, Swarbrick said Notre Dame did not go public with its findings sooner because it expected the Te'o family to come forward first.

Asked if the NCAA was monitoring the Te'o story for possible rules violations, NCAA President Mark Emmert said:

"We don't know anything more than you do," he told reporters at the organization's convention in Dallas. "We're learning about this through the stories just the same as you are. But we have to wait and see what really transpired there. It's obviously (a) very disturbing story and it's hard to tell where the facts lie at this point.

"But Notre Dame is obviously looking into it and there will be a lot more to come forward. Right now, it just looks ... well, we don't know what the facts are, so I shouldn't comment beyond that."

Reporters were turned away at the main gate of IMG's sprawling, secure complex. Te'o remained on the grounds, said a person familiar with situation who spoke on condition of anonymity because neither Te'o nor IMG authorized the release of the information.

"This whole thing is so nutsy that I believe it only could have happened at Notre Dame, where mythology trumps common sense on a daily basis. ... Given the choice between reality and fiction, Notre Dame always will choose fiction," sports writer Rick Telander said in the Chicago Sun-Times.

"Which brings me to what I believe is the real reason Te'o and apparently his father, at least went along with this scheme: the Heisman Trophy.

Chicago Tribune columnist John Kass blasted both Te'o and Notre Dame.

"When your girlfriend dying of leukemia after suffering a car crash tells you she loves you, even if it might help you win the Heisman Trophy, you check it out," he said.

He said the university's failure to call a news conference and go public sooner means "Notre Dame is complicit in the lie."

"The school fell in love with the Te'o girlfriend myth," he wrote.

___

AP Sports Writers Ralph Russo and Tim Reynolds contributed to this report.

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Life, Interrupted: Brotherly Love

Life, Interrupted

Suleika Jaouad writes about her experiences as a young adult with cancer.

There are a lot of things about having cancer in your 20s that feel absurd. One of those instances was when I found myself calling my brother Adam on Skype while he was studying abroad in Argentina to tell him that I had just been diagnosed with leukemia and that — no pressure — he was my only hope for a cure.

Today, my brother and I share almost identical DNA, the result of a successful bone marrow transplant I had last April using his healthy stem cells. But Adam and I couldn’t be more different. Like a lot of siblings, we got along swimmingly at one moment and were in each other’s hair the next. My younger brother by two years, he said I was a bossy older sister. I, of course, thought I knew best for my little brother and wanted him to see the world how I did. My brother is quieter, more reflective. I’m a chronic social butterfly who is probably a bit too impulsive and self-serious. I dreamed of dancing in the New York City Ballet, and he imagined himself playing in the N.B.A. While the sounds of the rapper Mos Def blared from Adam’s room growing up, I practiced for concerto competitions. Friends joked that one of us had to be adopted. We even look different, some people say. But really, we’re just siblings like any others.

When I was diagnosed with cancer at age 22, I learned just how much cancer affects families when it affects individuals. My doctors informed me that I had a high-risk form of leukemia and that a bone marrow transplant was my only shot at a cure. ‘Did I have any siblings?’ the doctors asked immediately. That would be my best chance to find a bone marrow match. Suddenly, everyone in our family was leaning on the little brother. He was in his last semester of college, and while his friends were applying to jobs and partying the final weeks of the school year away, he was soon shuttling from upstate New York to New York City for appointments with the transplant doctors.

I’d heard of organ transplants before, but what was a bone marrow transplant? The extent of my knowledge about bone marrow came from French cuisine: the fancy dish occasionally served with a side of toasted baguette.

Jokes aside, I learned that cancer patients become quick studies in the human body and how cancer treatment works. The thought of going through a bone marrow transplant, which in my case called for a life-threatening dose of chemotherapy followed by a total replacement of my body’s bone marrow, was scary enough. But then I learned that finding a donor can be the scariest part of all.

It turns out that not all transplants are created equal. Without a match, the path to a cure becomes much less certain, in many cases even impossible. This is particularly true for minorities and people from mixed ethnic backgrounds, groups that are severely underrepresented in bone marrow registries. As a first generation American, the child of a Swiss mother and Tunisian father, I suddenly found myself in a scary place. My doctors worried that a global, harried search for a bone marrow match would delay critical treatment for my fast-moving leukemia.

That meant that my younger brother was my best hope — but my doctors were careful to measure hope with reality. Siblings are the best chance for a match, but a match only happens about 25 percent of the time.

To our relief, results showed that my brother was a perfect match: a 10-out-of-10 on the donor scale. It was only then that it struck me how lucky I had been. Doctors never said it this way, but without a match, my chances of living through the next year were low. I have met many people since who, after dozens of efforts to encourage potential bone marrow donors to sign up, still have not found a match. Adding your name to the bone marrow registry is quick, easy and painless — you can sign up at marrow.org — and it just takes a swab of a Q-tip to get your DNA. For cancer patients around the world, it could mean a cure.

The bone marrow transplant procedure itself can be dangerous, but it is swift, which makes it feel strangely anti-climactic. On “Day Zero,” my brother’s stem cells dripped into my veins from a hanging I.V. bag, and it was all over in minutes. Doctors tell me that the hardest part of the transplant is recovering from it. I’ve found that to be true, and I’ve also recognized that the same is true for Adam. As I slowly grow stronger, my little brother has assumed a caretaker role in my life. I carry his blood cells — the ones keeping me alive — and he is carrying the responsibility, and often fear and anxiety, of the loving onlooker. He tells me I’m still a bossy older sister. But our relationship is now changed forever. I have to look to him for support and guidance more than I ever have. He’ll always be my little brother, but he’s growing up fast.

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Suleika Jaouad (pronounced su-LAKE-uh ja-WAD) is a 24-year-old writer who lives in New York City. Her column, “Life, Interrupted,” chronicling her experiences as a young adult with cancer, appears regularly on Well. Follow @suleikajaouad on Twitter.

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Advertising: Some Marketers Rethink Super Bowl Ad Previews

FEW on Madison Avenue who emulate the habits of highly effective people would admit to borrowing from the Nixon White House. But as marketers that will advertise in Super Bowl XLVII plan pregame strategies, many are opting for what was described during the Watergate era as a modified limited hangout.

Those marketers, which include Kraft Foods and Procter & Gamble, are deciding they will share part — but not all — of their Super Bowl commercials before the spots are broadcast by CBS on Feb. 3. Their decisions stand in contrast to what brands like Acura and Volkswagen did in the last two Super Bowls: offer consumers opportunities, days or weeks before the games, to watch online the entire spots or longer versions.

The increasing willingness of consumers to share information about Super Bowl ads on social media like Facebook, Twitter and YouTube has been encouraging sponsors to provide sneak peeks of the commercials. That departed from what Super Bowl sponsors had done for decades: stay mum, hoping to capitalize on the element of surprise to stimulate conversation and coverage.

But some executives say they see disadvantages to previewing Super Bowl spots in full because doing so could diminish, to use a term from another White House, the shock and awe.

“Right now, our plan is to hold back the spot till the day of the game,” said Chris Lillich, associate marketing director for North America laundry at Procter & Gamble, which will run a 30-second spot for Tide in the third quarter.

Providing full commercials in advance is “certainly a valid strategy,” Mr. Lillich said. “But we think doing the ‘big reveal’ in the game is going to do the best for us.”

Procter is scheduling a “significant” teaser campaign to begin next week, which ought to “generate a lot of buzz and still allow us to have that ‘big reveal,’ ” he said.

The Tide commercial, by Saatchi & Saatchi in New York, part of the Publicis Groupe, will feature the two teams to face each other in Super Bowl XLVII. It comes at the end of the first season of a multiyear deal designating Tide as the official detergent of the National Football League.

Kraft, like Procter, also intends to run a 30-second commercial in the third quarter of the game. The Kraft spot will be for MiO Fit, a new variety of its MiO line of “liquid water enhancer” that is to compete with sports beverages. Like Procter, Kraft will run a teaser campaign for its spot but resist the full Monty until the game.

“It has become more expected to do the prerelease,” said Doug Weekes, vice president for refreshment beverages at Kraft, and “it’s very tempting.”

But the concern is that previews would make the MiO Fit commercial “just a little bit less special,” Mr. Weekes said. “We prefer keeping it a surprise for our consumers.”

The star of the MiO Fit spot, by the New York office of Taxi, part of WPP, is the comedian Tracy Morgan. Just as the content of the commercial will be “totally unexpected” by viewers, said Michael Pierantozzi, co-executive creative director at Taxi New York, Mr. Morgan “is a totally unexpected sports-drink spokesman.”

“It’s a big, fun spot,” Mr. Pierantozzi said. “We wanted to save it for the Super Bowl because it’s the kind of spot you need to watch on the big screen on Super Bowl Sunday.”

Other marketers said they considered the surprise-and-delight approach before determining the revelatory route would be more rewarding.

“For me, it’s all about maximizing exposure,” said Steve Cannon, president and chief executive at Mercedes-Benz USA, which will run in the fourth quarter a one-minute commercial, by Merkley & Partners in New York, an Omnicom Group agency, for the 2014 CLA small coupe.

Even if millions of people watch the commercial online before the game, “it’s still going to be brand-new for 98 percent of the population,” he said, and such previews help defray the “big expense” of buying time in the game.

Five CLA teasers are to begin on television on Sunday, using the Rolling Stones song to be heard in the Super Bowl spot, “Sympathy for the Devil.” (That’s a plot clue — hint, hint.) Ten days later, a preview of the Super Bowl spot, in the form of a 90-second version, is to appear on Facebook and YouTube.

On Jan. 28, the Taco Bell division of Yum Brands plans a preview of its one-minute spot that will run in the second or third quarter of the Super Bowl. “Why not reward the people who love you?” asked Brian Niccol, chief marketing and innovation officer at Taco Bell. “I don’t think it does anything but amplify.”

Employee previews are planned, too. “We have access to all our restaurants via the Internet, and we’ll use that to share the ad,” Mr. Niccol said. “There are no bigger advocates for the brand than our team members.”

The plot of the Taco Bell commercial, about an unexpected night out for a group of aging friends, is evocative of “Cocoon” or the “Kick the Can” segment of “Twilight Zone: the Movie.” The spot will feature a Spanish version of the hit song “We Are Young.”

The agency creating the Taco Bell commercial — Deutsch L.A., part of the Interpublic Group of Companies — created the Volkswagen commercials in the 2011 and 2012 Super Bowls that benefited mightily from early releases of longer versions on YouTube.

“The people who viewed them and shared them before the games were the ones to tell everyone at the Super Bowl parties, ‘Quiet down, here comes that Volkswagen spot,’ ” said Michael Sheldon, chief executive at Deutsch L.A.

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Pakistan Rejects Preacher’s Politics and Says He Is at Risk

ISLAMABAD, Pakistan — Two days after a charismatic preacher swept into the capital surrounded by thousands of supporters, Pakistan’s government responded by rejecting his political agenda and hinting that an operation to dislodge him was imminent.

Interior Minister Rehman Malik told reporters on Wednesday that there were indications that suicide bombers planned to target the preacher, Muhammad Tahir-ul Qadri, who is in a bulletproof container near Parliament.

Mr. Qadri and his boisterous supporters, estimated at 25,000 people, could be the subject of a “targeted operation” as early as Thursday, Mr. Malik said. “For the safety of the women and children in the protest, I request you to leave by tomorrow,” he said at a news conference.

Mr. Qadri, 61, who has demanded that the government resign to make way for a caretaker administration, insisted that he was standing firm, but also suggested the standoff could be resolved within a couple of days, although he declined to specify how.

“We are in the victory zone and about to achieve our target,” he told The New York Times, speaking inside the fortified container, mounted on the back of a truck, from which he has delivered several fiery speeches. “The march will be successful in the next one or two days at most.”

Earlier, the information minister, Qamar Zaman Kaira, mocked Mr. Qadri’s demands at a news conference, and accused him of using the many women and children among his supporters as “human shields.” But Mr. Kaira said, “The people will not stand by him.” The government was showing some teeth after Mr. Qadri managed to lead his supporters into the capital, despite numerous obstacles, leaving officials looking outwitted.

The government’s authority was also challenged on Tuesday by the Supreme Court, which ordered the arrest of the prime minister, Raja Pervez Ashraf, as part of a corruption prosecution. The government has signaled that it intends to challenge the order when the case comes to court on Thursday morning; officials see the move as part of a long-running proxy battle between the chief justice, Iftikhar Muhammad Chaudhry, and the president, Asif Ali Zardari.

Pakistan’s military, meanwhile, has been grappling with its longtime foe India in the disputed province of Kashmir, where at least five soldiers from both sides have died in a series of skirmishes over the past two weeks.

In the latest episode, Pakistan said Wednesday that Indian troops had shot a Pakistani soldier at a position named Kundi, and lodged an official complaint with New Delhi. India denied responsibility. The tensions have raised worries that months of steady diplomatic progress between the rival neighbors could be undone. But hopes for a resolution of the dispute rose late on Wednesday when, after a phone conversation between senior commanders on both sides, India said an agreement to calm the situation had been reached.

Pakistan’s director general of military operations, Maj. Gen. Ashfaq Nadeem, spoke for 10 minutes with his Indian counterpart, Lt. Gen. Vinod Bhatia, an Indian spokesman told reporters.

The spokesman, Col. Jagdeep Dahiya, told Agence France-Presse that the Pakistani general “said strict instructions have been passed not to violate the cease-fire.”

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BlackBerry maker plans local skate, publicity in Waterloo to celebrate new phone

WATERLOO, Ont. – Call it BlackBerry Town, even if the name isn’t official.

In the lead up to the BlackBerry smartphone unveiling later this month, creator Research In Motion is turning its Waterloo, Ont., home base into a celebration of the device.

The company plans to decorate light poles in areas of Waterloo and neighbouring Kitchener with banners that promote its latest smartphone and thank the community for its support.

City councillors in Kitchener voted earlier this week to make an exception to rules that prevent corporations from using public property to advertise.

RIM says it is making plans for other events as well.

The company will hold skating rink parties at Kitchener City Hall and in Waterloo Town Square on Jan. 30 to coincide with the unveiling of its new BlackBerry devices.

Gadgets News Headlines – Yahoo! News

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Story of Te'o girlfriend death apparently a hoax

SOUTH BEND, Ind. (AP) — A story that Notre Dame football star Manti Te'o's girlfriend had died of leukemia — a loss he said inspired him to help lead the Irish to the BCS championship game — was dismissed by the university Wednesday as a hoax perpetrated against the linebacker.

Notre Dame athletic director Jack Swarbrick says his faith has not been shaken in Te'o "one iota."

Swarbrick says an investigation by a firm the school hired has convinced him that Te'o was duped into an online relationship with a woman whose death was then faked by the perpetrators of the hoax.

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Study Confirms Benefits of Flu Vaccine for Pregnant Women

While everyone is being urged to get the flu vaccine as soon as possible, some pregnant women avoid it in the belief that it may harm their babies. A large new study confirms that they should be much more afraid of the flu than the vaccine.

Norwegian researchers studied fetal death among 113,331 women pregnant during the H1N1 flu pandemic of 2009-2010. Some 54,065 women were unvaccinated, 31,912 were vaccinated during pregnancy, and 27,354 were vaccinated after delivery. The scientists then reviewed hospitalizations and doctor visits for the flu among the women.

The results were published on Thursday in The New England Journal of Medicine.

The flu vaccine was not associated with an increased risk for fetal death, the researchers found, and getting the shot during pregnancy reduced the risk of the mother getting the flu by about 70 percent. That was important, because fetuses whose mothers got the flu were much more likely to die.

Unvaccinated women had a 25 percent higher risk of fetal death during the pandemic than those who had had the shot. Among pregnant women with a clinical diagnosis of influenza, the risk of fetal death was nearly doubled. In all, there were 16 fetal deaths among the 2,278 women who were diagnosed with influenza during pregnancy.

Dr. Marian Knight, a professor at the perinatal epidemiology unit of the University of Oxford, who was not involved in the research, called it “a high-quality national study” that shows “there is no evidence of an increased risk of fetal death in women who have been immunized. Clinicians and women can be reassured about the safety of the vaccine in the second and third trimesters of pregnancy.”

The Norwegian health system records vaccinations of individuals and maintains linked registries to track effects and side effects. The lead author, Dr. Camilla Stoltenberg, director of the Norwegian Institute of Public Health, said that there are few countries with such complete records.

“This is a great study,” said Dr. Denise J. Jamieson, an obstetrician and a medical officer at the Centers for Disease Control and Prevention, who was not involved in the work. “It’s nicely done, with good data, and it’s additional information about the importance of the flu vaccine for pregnant women. It shows that it’s effective and might reduce the risk for fetal death.”

In Norway, the vaccine is recommended only in the second and third trimesters, so the study includes little data on vaccination in the first trimester. The C.D.C. recommends the vaccine for all pregnant women, regardless of trimester.

“We knew from other studies that the vaccine protects the woman and the newborn,” Dr. Stoltenberg said. “This study clearly indicates that it protects fetuses as well. I seriously suggest that pregnant women get vaccinated during every flu season.”

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Flublok, a Flu Vaccine, Wins F.D.A. Approval

A new type of flu vaccine won regulatory approval on Wednesday, and its manufacturer said that limited supplies are expected to be available this winter.

The vaccine, developed by a small company called Protein Sciences, is made with a process that does not require the virus to be grown in chicken eggs, as is now generally done. That means a vaccine could be ready weeks earlier in the event of a pandemic.

“This approval represents a technological advance in the manufacturing of an influenza vaccine,” Dr. Karen Midthun, a senior official at the Food and Drug Administration, said in a statement announcing the agency’s approval of the product, which is called Flublok.

The approval comes during one of the more severe flu seasons in recent years, with many Americans rushing to find diminishing supplies of vaccine and spot shortages being reported.

Manon Cox, the chief executive of Protein Sciences, said the company could have about 150,000 doses ready to distribute later this flu season. That is a relatively small amount, but it could be particularly helpful for people who do not get flu shots now because they are allergic to eggs.

A spokeswoman for the F.D.A. said the timing of the approval was unrelated to the current flu season.

Most flu vaccines are made by growing the virus in chicken eggs, then inactivating or killing it, a long process.

Flublok, by contrast, consists only of a protein — hemagglutinin — from the virus. The protein is made by putting the gene for hemagglutinin into a virus that infects insect cells. Those cells, from the fall armyworm, are grown in culture and churn out the protein. Neither eggs nor the live virus are used, though viral genetic information is needed.

While new for flu, such protein-based vaccines are used to prevent some other diseases.

Protein Sciences, a privately held company in Meriden, Conn., first applied for approval nearly five years ago. It was turned down twice, in part because of the novelty of using insect cells. “Every time we were asked to do more and more studies to prove that this cell substrate was safe,” Ms. Cox said.

The company was close to bankruptcy in 2009 when it received a federal contract worth tens of millions of dollars to help develop its vaccine.

The vaccine is approved only for adults 18 to 49 years old. In a clinical trial, Flublok was about 44.6 percent effective against all influenza strains, not just the three contained in the vaccine, the F.D.A. said. As with current vaccines, Flublok will need to change each year to match the flu strains in circulation.

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